1. What should I do if I miss a dose?
Take the next dose as soon as you remember. Do not take extra tablets to make up for the missed dose.
What is Atovaquone/Proguanil 250mg/100mg?
Atovaquone/Proguanil 250mg/100mg is a prescription medicine used to prevent and treat malaria a serious infection spread by mosquito bites in certain parts of the world. It is the generic version of Malarone.
It contains two active ingredients that work together to stop the malaria parasite from surviving and multiplying in the body.
What it can be used for:
- Prevention of malaria when travelling to malaria-risk areas
- Treatment of uncomplicated malaria , particularly caused by Plasmodium falciparum
- Atovaquone 250mg – interferes with the parasite’s energy production
- Proguanil 100mg – prevents the parasite from multiplying and enhances the effect of atovaquone
Who is it suitable for?
Suitable for:
- Adults
- Adolescents and children weighing over 40kg(for the 250mg/100mg strength)
- Travellers visiting malaria-endemic areas
Not suitable for:
- People allergic to atovaquone or proguanil
- People with severe kidney problems unless advised by a specialist
Always inform your prescriber of any medical conditions or other medicines you are taking.
How to take Atovaquone/Proguanil 250mg/100mg
Take exactly as prescribed and read the patient information leaflet before use.
For malaria prevention:
- Take 1 tablet once daily
- Start 1–2 days before travel to a malaria-risk area
- Continue daily during your stay
- Continue for 7 days after leaving the area
For malaria treatment:
- The dose may differ and is usually taken for 3 days
- Follow your prescriber’s instructions carefully
Important advice:
- Take with food or a milky drink to improve absorption
- Complete the full course
- If you miss a dose, take it as soon as you remember
- Do not take a double dose
Malaria prevention tablets do not replace mosquito bite protection. Use nets, repellents, and protective clothing.
Side effects
Not everyone experiences side effects.
Common side effects:
- Headache
- Nausea or vomiting
- Stomach pain or diarrhoea
- Feeling tired or weak
- Fever
Seek urgent medical attention if you experience:
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or swallowing
- Severe rash or hives
If you notice any other unusual symptoms, speak to your GP or pharmacist.
Pregnancy and breastfeeding
Speak to your doctor before taking this medicine if you are pregnant, planning pregnancy, or breastfeeding.
Storage
- Store below 25°C
- Keep in original packaging
- Keep out of the sight and reach of children
- Do not use after the expiry date
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Frequently Asked Questions
2. Can I take other medicines with it?
Some medicines may interact, so tell your doctor about any other medicines you are taking.
3. Can I take it if I am pregnant or breastfeeding?
Only if a doctor advises it is not generally recommended during pregnancy or breastfeeding.
4. How should I take it for prevention?
Take one tablet daily with food starting 1–2 days before travel, every day while in the risk area, and for 7 days after leaving.
Our Clinical Authors
Written by
Omar El-Gohary
CEO & Superintendent Pharmacist | GPhC Registration: 2059792
Medically reviewed by
Jabbar Ali
MPharm Clinical Lead | GPhC Registration: 2205490
This page has been written by a registered UK pharmacist and reviewed by our clinical team to ensure it is accurate, clear and reflects current clinical guidance.
Last medically reviewed: 20 August 2026
Last updated: 21 August 2026