Cialis Together belongs to a class of drug known as phosphodiesterase-5 inhibitors (PDE5i). It is a type of drug that is used to treat erectile dysfunction and benign prostatic hyperplasia.
How Does Cialis Together Work in Tackling Erectile Dysfunction?
To properly understand how Cialis Together works towards treating ED, it's necessary to first understand how erections work. When there is an erotic stimulus (physical touch, erotic thoughts, sensual scents, etc.), local tissues emit nitric oxide (NO), which raises the quantity of a molecule called cyclic guanosine monophosphate (cGMP). cGMP relaxes the corpora cavernosa muscles, allowing blood to flow into the penis.
Simultaneously, veins releasing blood from the penis become constricted, allowing more blood to become trapped in the penis, leading to an erection. Phosphodiesterase-5 is an enzyme that breaks down cGMP, causing the penis to revert to its flaccid state. PDE5 inhibitors, such as Cialis, inhibit this enzyme, resulting in increased amounts of cGMP and a better ability to get and maintain an erection.
Directions for Using Cialis Together
Cialis Together should be taken 30–60 minutes before sexual activity with other men or women. Cialis Together is a long-acting medicine that can remain active in your body for up to 36 hours, which is why it is known as a "weekend pill".
When Cialis Together is taken at least 2 hours before sex with other men or women, some people have better results. Food does not affect Cialis Together absorption, so it can be taken with or without food.
Side Effects of Cialis Together
Some of the common side effects of Cialis Together are:
- Nausea
- Flushing
- Muscle pain
- A stuffy or runny nose
- An upset stomach
- Headache
If you experience any of these common side effects and they either persist or become worse, get it examined by a doctor. Moreover, if you experience any unforeseen side effects, you should still talk to a doctor.
In some rare cases, Cialis Together can cause some severe side effects. These include:
- A sudden decline in hearing ability. This may surface in the form of Tinnitus (ringing in the ears) and/or dizziness
- A sudden loss of vision in one or both eyes. For example, one may experience non-arteritic anterior ischemic optic neuropathy, which is an eye condition that causes sudden vision loss in one or both eyes (NAION).
- An excessively prolonged erection (priapism). In such a case, the erection may last for several hours.
If you experience hearing or vision loss, or if your erection lasts for more than four hours, do not take Cialis Together any further and seek medical attention immediately.
Warnings When Using Cialis Together
You should not take Cialis Together if you:
- Take nitrate medications. Nitrates are a type of drug used to treat high blood pressure (such as nitroglycerin).
- Are allergic to Cialis Together or any of the ingredients in Cialis.
- Take guanylate cyclase stimulators like Riociguat (Adempas).
To ensure that Cialis Together is safe for you, share your comprehensive medical history with the doctor. This may include telling if you have:
- History of a heart attack, or have an irregular heartbeat, angina, chest pain, aortic valve narrowing, or heart failure
- Pulmonary hypertension
- Had an erection that lasted longer than 4 hours
- Unregulated high blood pressure or low blood pressure
- Liver problem
- Blood cell disorders like sickle cell anaemia, multiple myeloma, or leukaemia
- Malformed penis
- Recently suffered a stroke
- Stomach or intestinal ulcers
- Any other medical issue
Also, tell your doctor about all of the medications you are taking, including prescriptions and over-the-counter medications, vitamins, and herbal supplements.
Cialis Together may impact the way other medications function and may result in adverse effects.
Our Clinical Authors
This page has been written by a registered UK pharmacist and reviewed by our clinical team to ensure it is accurate, clear and reflects current clinical guidance.
Last medically reviewed: 03 June 2026
Last updated: 03 June 2026