What is Calpol SixPlus Suspension Sugar Free?
Calpol SixPlus Suspension Sugar Free is an oral liquid medicine used to relieve pain and reduce fever in children aged 6 years and over. It contains paracetamol (250mg in every 5ml). Paracetamol works by acting on the brain to reduce pain and helps lower body temperature during a fever.
Calpol SixPlus helps to:
- Reduce fever by acting on the body’s temperature control centre
- Relieve mild to moderate pain such as headache, sore throat, toothache, earache, and muscle aches
- Reduce discomfort associated with colds, flu, and post-immunisation reactions
Overall, it helps improve comfort without causing drowsiness or stomach irritation when used as directed.
Who is Calpol SixPlus Suspension Sugar Free suitable for?
Calpol SixPlus Suspension Sugar Free is suitable for:
- Children aged 6 years and over
- Teenagers and adults requiring liquid paracetamol
Important advice when using this medicine:
- Do not give more than 4 doses in 24 hours
- Leave at least 4 hours between doses
- Do not use for more than 3 days without medical advice
Do not give alongside other medicines containing paracetamol.
How to take Calpol SixPlus Suspension Sugar Free
You should always use this medicine exactly as directed on the packaging or by your pharmacist or doctor.
Dose recommendations (up to 4 times daily)
- Children aged 6–8 years: 5ml
- Children aged 8–10 years: 7.5ml (5ml + 2.5ml)
- Children aged 10–12 years: 10ml (5ml + 5ml)
- Children aged 12–16 years: 10–15ml (two to three 5ml doses)
- Adults and children over 16 years: 10–20ml (two to four 5ml doses)
Always leave at least 4 hours between doses.
Typical use
- For oral use only
- Always use the dosing syringe supplied
- Shake the bottle for at least 10 seconds before use
- Do not give more medicine than recommended
Do not give any other medicines containing paracetamol at the same time.
How to use the syringe
- Shake the bottle well and remove the cap
- Insert the syringe into the plug in the bottle neck
- Draw out the exact dose required
If you forget to give the medicine Give the next dose when needed, provided at least 4 hours have passed since the previous dose. Do not give a double dose.
If too much medicine is taken Speak to a doctor immediately, even if your child seems well. Too much paracetamol can cause serious delayed liver damage.
Symptoms may include:
- Nausea or vomiting
- Sweating
- Loss of appetite
- Stomach pain or discomfort
Adults who regularly drink large amounts of alcohol should seek medical advice before use.
How to store Calpol SixPlus Suspension Sugar Free
- Store below 25°C
- Keep in the original packaging
- Keep out of the sight and reach of children
- Do not use after the expiry date shown on the packaging
Ask your pharmacist how to dispose of medicines you no longer use.
Side effects
Like all medicines, Calpol SixPlus can cause side effects, although not everyone gets them.
Common or mild side effects include:
- Nausea or vomiting
- Stomach upset
- Loose stools or tummy discomfort caused by sugar-free sweeteners
Rare but serious side effects include:
- Allergic reactions such as rash, swelling, or breathing difficulty
- Severe skin reactions including blistering or peeling skin
- Signs of liver problems such as yellowing of skin or eyes, dark urine, or unusual tiredness
Stop using the medicine and seek medical advice immediately if serious side effects occur.
When to seek medical help
- Call emergency services for severe allergic reactions
- Seek urgent advice if too much medicine has been taken
- Speak to a doctor if symptoms last longer than 3 days or worsen.
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Our Clinical Authors
This page has been written by a registered UK pharmacist and reviewed by our clinical team to ensure it is accurate, clear and reflects current clinical guidance.
Last medically reviewed: 06 July 2026
Last updated: 06 July 2026