What Happens When You Stop Weight Loss Injections Like Mounjaro or Wegovy?

30 December, 2025  |  Holy Winter - Healthcare Writer

Thinking about stopping your weight loss injections? iQ Doctor explains what happens next, how to avoid regaining weight, and how to maintain your progress safely.

Weight loss injections like Mounjaro and Wegovy have helped many people achieve significant results. However, if you’ve reached your goal or are considering stopping treatment, it’s natural to wonder: what happens when you stop taking weight loss injections?

Here, iQ Doctor explains what to expect after discontinuing treatment and how to maintain your weight loss long-term.

How Weight Loss Injections Work

Medications such as semaglutide (sold under brand names like Ozempic and Wegovy) mimic a natural hormone called GLP-1. This hormone regulates appetite, slows digestion, and helps control blood sugar levels.

By increasing the feeling of fullness and reducing hunger, these weekly injections make it easier to consume fewer calories and lose weight gradually over time.

What Happens When You Stop Taking Weight Loss Injections

When you stop treatment, your body gradually returns to its natural hormone balance. This can lead to several changes:

1. Appetite Returns

   The appetite-suppressing effect of GLP-1 medications fades, which may make you feel hungrier than before and more likely to give in to food cravings.

2. Metabolism Slows Down

   After losing weight, your metabolism may adapt by burning fewer calories. Without ongoing treatment or lifestyle adjustments, this can make it easier to regain weight.

3. Possible Weight Regain

   Studies show that most people regain a portion of the weight they lost if they stop injections suddenly without a maintenance plan, ultimately halting your weight loss journey.

4. Blood Sugar and Cravings May Fluctuate

   If you were prescribed injections for both weight and blood sugar management, you may notice increased cravings for carbohydrates or changes in glucose control.

How to Prevent Weight Regain After Stopping

Stopping weight loss injections doesn’t have to mean undoing your hard work. With the right support and lifestyle habits, you can maintain your results effectively:

• Transition Gradually: Don’t stop abruptly without medical guidance. Your prescriber may recommend tapering off or switching to an alternative treatment.
• Focus on Nutrition: Prioritise balanced reduced calorie diet plans with lean protein, fibre, and healthy fats to keep you full longer.
• Stay Active: Regular physical activity helps maintain metabolism and muscle mass.
• Monitor Weight Changes: Track your progress and adjust your diet or exercise routine early if you notice small increases.
• Seek Ongoing Support: Clinics like iQ Doctor can help you develop a sustainable plan that fits your lifestyle.

Can You Restart Weight Loss Injections?

Yes - in some cases, patients can restart treatment if significant weight regain occurs. However, this should always be done under the supervision of a qualified healthcare professional. iQ Doctor can guide you on whether restarting medication is appropriate and safe for your circumstances.

The Bottom Line

When you stop taking weight loss injections, your appetite and metabolism will gradually return to their pre-treatment state. However, maintaining healthy habits — such as balanced eating and regular exercise — can help preserve your progress and support long-term well-being.

If you’re considering stopping your injections or want to maintain your results safely, speak to a licensed prescriber at iQ Doctor for professional guidance.

iQ Doctor is a registered UK pharmacy that specialises in medical remedies for weight loss (including Wegovy and Mounjaro), erectile dysfunction, hair loss support and much more. Whether you require over-the-counter relief, or prescription-only medication, the experts at iQ Doctor can assist. Please get in touch if you need any further advice.

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