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How To Take Malarone One tablet daily with food or a milky drink at about the same time each day. Start taking the tablets 1-2 days before you enter the malaria area and continue until one week after you leave. Side Effects of Malarone Side effects with Malarone are less common and severe than other anti-malaria drugs. Side effects may include: rashes, abdominal pain, headaches, anorexia, nausea, diarrhoea, dizziness, change in sleep pattern, coughing and mouth ulcers.