What is E45 Itch Relief Cream?
E45 Itch Relief Cream helps soothe and treat itchy, dry, and irritated skin. It contains an anti-itch ingredient that calms irritation and helps break the itch–scratch cycle.
It also contains urea (5%), a natural moisturiser that helps draw moisture into the skin to rehydrate and soften dry, rough areas.
The cream is non-greasy, perfume-free, and dermatologically tested, helping leave the skin feeling calm and comfortable.
It can help with:
- Itchy skin caused by eczema
- Dermatitis-related itching
- Dry, irritated, or sensitive skin
- Rough, flaky skin
- Reducing scratching and skin damage
- Daily moisturising of dry or itchy skin
Active ingredients:
- Lauromacrogols – an anti-itch ingredient that helps calm irritation
- Urea 5% – a moisturiser that attracts and retains moisture in the skin
Who is E45 Itch Relief Cream suitable for?
E45 Itch Relief Cream is suitable for:
- Adults
- Children and babies aged 1 month and over
How to use E45 Itch Relief Cream
- Apply a thin layer to the affected area
- Gently massage into the skin until absorbed
- Apply twice daily (morning and evening), or as advised by a healthcare professional
Helpful tips:
- Use regularly to keep itching under control
- Apply after bathing to help lock in moisture
- Keep nails short to reduce skin damage from scratching
- Wear soft, breathable fabrics such as cotton
If symptoms do not improve, worsen, or you are concerned, speak to a doctor or pharmacist.
How to store E45 Itch Relief Cream
- Store at room temperature
- Keep the container tightly closed when not in use
- Keep away from excess heat and direct sunlight
- Keep out of sight and reach of children
- Do not use after the expiry date
Side effects are usually mild and uncommon.
Possible side effects include:
- Burning or stinging where the cream is applied
- Redness or itching
- Irritation if applied to broken or inflamed skin
Stop using the cream and seek medical advice if you develop signs of an allergic reaction, such as swelling, rash, or severe irritation.
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Our Clinical Authors
This page has been written by a registered UK pharmacist and reviewed by our clinical team to ensure it is accurate, clear and reflects current clinical guidance.
Last medically reviewed: 06 July 2026
Last updated: 06 July 2026