Why Thousands in the UK Are Switching from Mounjaro to Wegovy
22 August, 2025 | Jane Thomas - Marketing
As of September 2025, Mounjaro (tirzepatide) prices in the UK are rising steeply—causing many patients and providers to consider switching to Wegovy (semaglutide) as a safer, more affordable long-term option.
With both medications acting on GLP-1 receptors to suppress appetite and support weight loss, many wonder: Can I switch from Mounjaro to Wegovy safely? The answer is yes—but only under the guidance of a healthcare provider and following proper titration protocols.
Price Comparison: Mounjaro vs Wegovy in 2025
Medication | Dose | Price (Aug 2025) | Price (From Sept 2025) |
Mounjaro | 5mg | ~£92 | ~£180 |
Mounjaro | 15mg | ~£122 | ~£330 |
Wegovy | 2.4mg (max) | ~£200 | ~£200 (No change) |
How Wegovy Works Compared to Mounjaro
- Mounjaro: Dual-action (GLP-1 and GIP receptor agonist); slightly more effective on average, but newer and with higher side effect risk.
- Wegovy: Single-action (GLP-1 agonist); well-established, long-term safety, cardiovascular benefits, NICE-approved in the UK.
Safe Transition from Mounjaro to Wegovy: Step-by-Step Guide
- Always Consult a UK-Registered Prescriber
Before changing medications, consult your GP, obesity specialist, or pharmacy prescribing service to ensure it's appropriate for your:
> BMI and medical history
> Side effect tolerance
> Weight loss goals
Wegovy may be preferred by NICE for broader clinical use and reduced cardiovascular risk. - Pause Period Between Injections (Washout Phase)
A 7-day pause between your last Mounjaro dose and your first Wegovy injection is typically advised.
A2–4 week break may be required, especially, if GI side effects were present. - Start Wegovy at the Lowest Dose
Regardless of your previous Mounjaro strength, Wegovy must be started at 0.25 mg once per week to reduce nausea and side effects. Escalation occurs every 4 weeks.
Wegovy Titration Schedule (UK Standard)
Weeks | 1–4 | 5–8 | 9–12 | 13–16 | Week 17+ |
Weekly Wegovy Dose | 0.25 mg | 0.5 mg | 1.0 mg | 1.7 mg | 2.4 mg (Maintenance) |
Why Can't You Start Wegovy at a Higher Dose?
GLP-1 medications can cause nausea, vomiting, and dizziness—especially if started at too high a dose. Starting low allows your body to adjust and minimises side effects, improving long-term medication tolerance.
What to Expect During the Switch
- Week 1–2: Mild hunger return is normal as Mounjaro clears from your system. Begin Wegovy at 0.25 mg.
- Week 5–12: Appetite suppression returns as semaglutide levels build up.
- Week 17+: Most patients stabilise at 2.4 mg/week for long-term weight control.
NICE & NHS Guidance (2025 Update)
- NICE now supports longer-term use of Wegovy for obesity management.
- Patients are advised to receive structured support, including:
- Behavioural therapy
- Exercise programs
- Nutrition planning
- Wegovy can be prescribed through NHS Tier 3 services or privately.
Final Thoughts: Wegovy Is a Smart Switch for 2025
With Mounjaro becoming financially unsustainable for many UK patients, Wegovy offers a clinically safe, cost-effective, and NICE-endorsed alternative for weight loss.The key to switching safely?
Medical oversight, a clear washout period, and proper dose titration. Don't DIY it—always consult iQ Doctor for assistance.Reviewed By
Omar El-Gohary
The superintendent and lead pharmacist - registration number 2059792.
Omar is passionate about developing healthcare technology to empower our patients.
