Pros and Cons of Semaglutide for Weight Loss

10 November, 2025  |  Holy Winter - Healthcare Writer

Pros and Cons of Semaglutide for Weight Loss

Discover the pros and cons of semaglutide for weight loss. Learn about general semaglutide reviews, as well as discovering the potential side effects with iQ Doctor.

Semaglutide has quickly become one of the most talked-about treatments for weight loss in the UK and worldwide. Originally developed to help manage type 2 diabetes, semaglutide is now widely prescribed under brand names like Wegovy (for the UK market) for weight management.

But before starting any medication, it’s essential to understand both the benefits and drawbacks. Here, we explore the pros and cons of semaglutide for weight loss, supported by user experiences and semaglutide reviews.

What Is Semaglutide?

Semaglutide is a GLP-1 receptor agonist, a medication that mimics a natural hormone called GLP-1. This hormone helps regulate appetite and blood sugar levels. By slowing digestion and reducing hunger, semaglutide helps users consume fewer calories and achieve steady, sustainable weight loss.

It is available under several brand names:

• Wegovy – specifically licensed for weight management.
• Ozempic – primarily for diabetes but often used off-label for weight loss.
• Mounjaro (Tirzepatide) (not semaglutide) – a dual-action alternative with similar appetite-suppressing effects.

The Pros of Semaglutide for Weight Loss

1. Proven Weight Loss Results

Clinical studies and countless semaglutide reviews highlight its impressive results. Many patients lose over several months of consistent use when paired with lifestyle changes.

2. Reduces Appetite Naturally

Unlike stimulant-based weight loss treatments, semaglutide works with your body’s natural hormone signals to reduce appetite and cravings—making it easier to maintain a calorie deficit.

3. Helps Manage Blood Sugar

As a GLP-1 agonist, semaglutide improves blood sugar control, making it beneficial for those with type 2 diabetes or insulin resistance.

4. May Improve Cardiovascular Health

Some studies suggest semaglutide can lower the risk of heart-related issues by improving cholesterol levels and reducing inflammation.

5. Simple Weekly Dosing

Semaglutide injections are taken once per week, offering convenience and consistency compared to daily pills or injections.

The Cons of Semaglutide for Weight Loss

1. Possible Side Effects

Common semaglutide side effects include:

• Nausea or vomiting
• Diarrhoea or constipation
• Fatigue
• Headaches

These usually subside over time as your body adjusts to the treatment, but some users report persistent discomfort in semaglutide weight loss reviews.

2. Cost and Accessibility

Semaglutide can be expensive privately, especially without insurance or NHS coverage. Prices may vary between brands of semaglutide-based weight loss medication.

3. Requires Commitment

Stopping semaglutide abruptly can lead to weight regain. For sustainable results, it should be part of a long-term lifestyle plan that includes balanced nutrition, exercise and increased *general* physical movement.

4. Weight Loss Medication is Not Suitable for Everyone

Semaglutide isn’t recommended for people with certain health conditions, including thyroid disorders, pancreatitis, or a history of severe gastrointestinal issues. Always consult a healthcare professional before starting treatment.

5. Gradual Dose Escalation

You’ll need to increase your dose slowly under medical supervision to minimise side effects—this can take several weeks to reach the optimal dose.

Semaglutide Reviews – What Do Users Say?

Many semaglutide weight loss reviews describe the treatment as life-changing and self-confidence affirming. Users often report steady, healthy weight loss with improved energy levels and reduced cravings.

However, others mention side effects such as nausea during the first few weeks or challenges maintaining results after stopping treatment. Individual experiences can vary significantly depending on lifestyle habits, diet, and medical history.

Conclusion

Semaglutide is one of the most effective medical weight loss treatments available today. While side effects and cost should be considered, most semaglutide reviews confirm its ability to deliver significant and sustained weight loss when used responsibly.

If you’re considering starting semaglutide or similar treatments like Wegovy or an alternative like Mounjaro, consult with an iQ Doctor clinician to determine the best and safest approach for your goals.

iQ Doctor is a registered UK pharmacy that specialises in medical remedies for weight loss, erectile dysfunction, hair loss support and much more. Whether you require over-the-counter relief, or prescription-only medication, the experts at iQ Doctor can assist. Please get in touch if you need any further advice.

Also, be sure to keep in touch with iQ Doctor via our social media channels as well as keeping up to date with us by signing up to the mailing list.

Frequently Asked Questions

1. How quickly does semaglutide work for weight loss?

Most users notice weight loss within 4–8 weeks, with significant results after several months of consistent use.

2. What are the common side effects of semaglutide?

Nausea, bloating, and fatigue are the most common. These typically decrease as your body adjusts to the medication.

3. Can I stop taking semaglutide once I lose weight?

Yes, but gradual discontinuation under medical supervision is advised to prevent rapid weight regain.

4. Is Mounjaro better than Wegovy as a weight management medication?

Both are effective. Mounjaro may offer faster weight loss results, but Wegovy remains the more established option in the UK.

5. Where can I buy semaglutide safely in the UK?

You can order genuine semaglutide weight loss treatments through iQ Doctor, a registered online pharmacy with UK-licensed prescribers.